Wenliang Wang Lab — Bridge-AD Lab

We are a research group focused on understanding the cellular and molecular mechanisms of Alzheimer’s Disease (AD) through the lens of single-cell epigenomics. By profiling both brain cells and immune cells at single-cell resolution, we aim to decode how gene regulation goes awry in AD and identify new therapeutic targets.

Our work sits at the intersection of epigenomics, neuroimmunology, computational biology, and AI, leveraging cutting-edge single-cell technologies including 10x Genomics, snm3C (joint single-nucleus DNA methylation + Hi-C), and spatial transcriptomics.

Research Highlights

• Single-cell epigenomics of human and mouse brain and immune cells to map cell-type-specific regulatory changes across AD progression
• Mechanisms of AD progression and prevention using mouse models and human induced neurons to dissect causal epigenomic and gene regulatory events
• Genetics × Environment AI model for precision prevention — integrating multi-omic data with environmental exposures to predict and prevent AD at the individual level
• Novel diagnostic and therapeutic strategies for AD — translating epigenomic discoveries into clinically actionable biomarkers and intervention targets

We Are Recruiting!

We are actively looking for motivated postdocs, graduate students, and undergraduate researchers to join the lab. If you are passionate about neuroscience, epigenomics, or computational biology, please reach out or see our Join Us page for details.

Recent News

See all news →